SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
Summary: Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also luce chandelier create unique vulnerabilities.Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly relapse with reactivation of the targeted pathways.We identify the nuclear protein SFP